Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 14/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 12/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | F13A1 | P00488 | 1/20 | 0.49 |
| ▸ | NQO2 | P16083 | 4/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851656 | 0.84 | MTNR1A (0.50) | MTNR1AMTNR1B | |
| SCHEMBL5988458 | 0.83 | MTNR1A (0.65) | MTNR1AMTNR1BMEN1LMNACYP1A2 | |
| SCHEMBL8229644 | 0.83 | MTNR1A (0.65) | MTNR1AMTNR1BMEN1LMNACYP1A2 | |
| SCHEMBL18607400 | 0.81 | MTNR1A (0.63) | MTNR1AMTNR1BMEN1LMNACYP1A2 | |
| SCHEMBL1011062 | 0.81 | MTNR1A (0.63) | MTNR1AMTNR1BMEN1LMNACYP1A2 | |
| SCHEMBL5987986 | 0.81 | MTNR1A (0.63) | MTNR1AMTNR1BMEN1LMNACYP1A2 | |
| SCHEMBL1039416 | 0.81 | MTNR1A (0.63) | MTNR1AMTNR1BMEN1LMNACYP1A2 | |
| SCHEMBL8851828 | 0.81 | HIF1A (0.57) | MTNR1AMTNR1BMEN1LMNAKMT2A | |
| SCHEMBL533866 | 0.80 | MTNR1A (0.61) | MTNR1AMTNR1BMEN1LMNACYP1A2 | |
| SCHEMBL1010214 | 0.80 | MTNR1A (0.61) | MTNR1AMTNR1BMEN1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |