SCHEMBL885225

SCHEMBL885225

COc1ccc(C(C=O)c2c(Cl)cncc2Cl)c(OCc2cccc(OC(F)(F)F)c2)c1OC

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 3/20 0.41
MTNR1A P48039 1/20 0.37
MTNR1B P49286 1/20 0.37
MAOB P27338 1/20 0.37
P2RX7 Q99572 1/20 0.36
ALOX5AP P20292 1/20 0.36
FEN1 P39748 1/20 0.36
USP28 Q96RU2 1/20 0.35
USP25 Q9UHP3 1/20 0.35
CTSA P10619 1/20 0.35
CHRM2 P08172 1/20 0.35
CHRM1 P11229 1/20 0.35
CHRM3 P20309 1/20 0.35
MRGPRX4 Q96LA9 2/20 0.35
CYP19A1 P11511 1/20 0.35
CYP11B1 P15538 1/20 0.35
CYP11B2 P19099 1/20 0.35
SCD O00767 1/20 0.34
SLC6A4 P31645 1/20 0.34
DYRK1A Q13627 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL885283 0.91 PDE4D (0.45) PDE4DMTNR1AMTNR1BMAOBMRGPRX4
SCHEMBL885278 0.88 PDE4D (0.42) PDE4DMRGPRX4
SCHEMBL885189 0.86 PDE4D (0.45) PDE4DMAOBMRGPRX4HTR1AADRA1D
SCHEMBL885186 0.85 PDE4D (0.56) PDE4DHTR1AADRA1DADRA1AADRA1B
SCHEMBL885308 0.83 PDE4D (0.44) PDE4D
SCHEMBL884902 0.82 PDE4D (0.47) PDE4DCHRM2CHRM1CHRM3SLC6A4
SCHEMBL885296 0.82 PDE4D (0.46) PDE4DP2RX7HTR1AADRA1DADRA1A
SCHEMBL885159 0.81 PDE4D (0.53) PDE4DHTR1AADRA1DADRA1AADRA1B
SCHEMBL885380 0.80 PDE4D (0.38) PDE4DP2RX7MRGPRX4
SCHEMBL885063 0.80 PDE4D (0.46) PDE4DHTR1AADRA1DADRA1AADRA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2125736-A1 SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS Leo Pharma A/S (DK) 2009-12-02 EP claimed
WO-2008077404-A1 SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS LEO PHARMA A/S (DK) 2008-07-03 WO claimed
EP-2125736-A1 SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS Leo Pharma A/S (DK) 2009-12-02 EP disclosed
WO-2008077404-A1 SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS LEO PHARMA A/S (DK) 2008-07-03 WO disclosed