Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | COL1A1 | P02452 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885283 | 0.91 | PDE4D (0.45) | PDE4DHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL885186 | 0.89 | PDE4D (0.56) | PDE4DHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL885063 | 0.88 | PDE4D (0.46) | PDE4DHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL885278 | 0.87 | PDE4D (0.42) | PDE4DMRGPRX4THRATHRBNPBWR1 | |
| SCHEMBL885308 | 0.86 | PDE4D (0.44) | PDE4DRAB9ANPBWR1 | |
| SCHEMBL885225 | 0.86 | PDE4D (0.41) | PDE4DHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL885159 | 0.85 | PDE4D (0.53) | PDE4DHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL885296 | 0.84 | PDE4D (0.46) | PDE4DHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL886771 | 0.83 | PDE4D (0.45) | PDE4D | |
| SCHEMBL885241 | 0.83 | PDE10A (0.41) | PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | claimed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | claimed |
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | disclosed |