Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5933082 | 0.88 | LMNA (0.45) | LMNATSHRCYP2D6MAPTALDH1A1 | |
| SCHEMBL30350415 | 0.78 | LMNA (0.45) | LMNATSHRCYP2D6MAPTALDH1A1 | |
| SCHEMBL8851220 | 0.76 | — | — | |
| SCHEMBL9234862 | 0.75 | LMNA (0.58) | LMNATSHRMAPTALDH1A1 | |
| SCHEMBL8851438 | 0.74 | LMNA (0.42) | LMNATSHRCYP2D6MAPTALDH1A1 | |
| SCHEMBL19231596 | 0.74 | — | — | |
| SCHEMBL10674424 | 0.74 | LMNA (0.38) | LMNATSHRCYP2D6MAPTALDH1A1 | |
| SCHEMBL8851023 | 0.73 | — | — | |
| SCHEMBL128684 | 0.72 | — | — | |
| SCHEMBL31019825 | 0.72 | LMNA (0.54) | LMNATSHRCYP2D6MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |