Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435174 | 0.88 | PDE10A (0.43) | PDE10APDE4DKLKB1PPARG | |
| SCHEMBL885308 | 0.88 | PDE4D (0.44) | PDE10APDE4DMEN1ALDH1A1MAPT | |
| SCHEMBL885063 | 0.84 | PDE4D (0.46) | PDE4DMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL885189 | 0.83 | PDE4D (0.45) | PDE4D | |
| SCHEMBL885296 | 0.82 | PDE4D (0.46) | PDE4DMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL886771 | 0.82 | PDE4D (0.45) | PDE4D | |
| SCHEMBL885186 | 0.81 | PDE4D (0.56) | PDE4DMEN1ALDH1A1KMT2A | |
| SCHEMBL885283 | 0.81 | PDE4D (0.45) | PDE4D | |
| SCHEMBL885278 | 0.78 | PDE4D (0.42) | PDE4DALDH1A1MAPT | |
| SCHEMBL4434300 | 0.78 | PDE4D (0.45) | PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | claimed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | claimed |
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | disclosed |