Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 19/20 | 0.47 |
| ▸ | RXRB | P28702 | 13/20 | 0.47 |
| ▸ | RXRG | P48443 | 13/20 | 0.47 |
| ▸ | RARB | P10826 | 11/20 | 0.47 |
| ▸ | RARG | P13631 | 10/20 | 0.47 |
| ▸ | RARA | P10276 | 7/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8853715 | 0.90 | RXRA (0.45) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8853733 | 0.90 | RXRA (0.45) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8853741 | 0.88 | RXRA (0.55) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8853737 | 0.88 | RXRA (0.55) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8853740 | 0.87 | CYP3A4 (0.46) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8853684 | 0.87 | CYP3A4 (0.46) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8853700 | 0.81 | RXRA (0.47) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8853661 | 0.81 | RXRA (0.47) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8854043 | 0.81 | RXRA (0.45) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8853795 | 0.81 | RXRA (0.45) | RXRARXRBRXRGRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696162-A | ANTIINFLAMMATORY AGENTS, SKIN DISORDERS, AUTOIMMUNE DISORDERS | ALLERGAN (US) | 1997-12-09 | — | — | US | claimed |
| WO-1995011242-A1 | PHENYL OR HETEROARYL AND TETRAHYDRONAPHTHYL SUBSTITUTED DIENE COMPOUNDS HAVING RETINOID LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1995-04-27 | — | — | WO | claimed |
| US-5696162-A | ANTIINFLAMMATORY AGENTS, SKIN DISORDERS, AUTOIMMUNE DISORDERS | ALLERGAN (US) | 1997-12-09 | — | — | US | disclosed |
| US-5677320-A | SKIN DISORDERS, ANTIGROWTH AGENT, IMMUNOLOGY DISORDERS | ALLERGAN (US) | 1997-10-14 | — | — | US | disclosed |
| US-5602135-A | SKIN DISORDERS, ANTIINFLAMMATORY AGENTS, ARTHEROSCLEROSIS,IMMUNOLOGY, WOUND HEALING AGENT, VISION DEFECTS, SUNSCREEN AGENTS | ALLERGAN | 1997-02-11 | — | — | US | disclosed |
| US-5475022-A | Treating acne | ALLERGAN, INC. (US) | 1995-12-12 | — | — | US | disclosed |