Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 2/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.34 |
| ▸ | TUBB | P07437 | 2/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.34 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855427 | 0.82 | HMGCR (0.43) | HMGCRPTGS2APPCYP2C19CASR | |
| SCHEMBL8855028 | 0.81 | HMGCR (0.42) | HMGCRPTGS2APPCYP2C19CASR | |
| SCHEMBL8854939 | 0.81 | FYN (0.44) | HMGCRCASRTUBB4ATUBBTUBA3C | |
| SCHEMBL8855220 | 0.79 | HMGCR (0.41) | HMGCRPTGS2APPCYP2C19CASR | |
| SCHEMBL8855082 | 0.79 | HMGCR (0.41) | HMGCRPTGS2APPCYP2C19CASR | |
| SCHEMBL8855279 | 0.79 | HMGCR (0.41) | HMGCRPTGS2APPCYP2C19GCGR | |
| SCHEMBL21547572 | 0.78 | TAAR1 (0.40) | PTGS2FABP4FABP5MAPTALOX12 | |
| SCHEMBL8855286 | 0.74 | HMGCR (0.47) | HMGCRPTGS2CYP2C19MEN1GAA | |
| SCHEMBL8855247 | 0.73 | HMGCR (0.42) | HMGCRCASRFYNGAA | |
| SCHEMBL16253659 | 0.72 | TAAR1 (0.43) | PTGS2FABP4FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599952-A | A 4-FLUOROBIPHENYL DERIVATIVE | FUJIREBIO INC. (JP) | 1997-02-04 | — | — | US | disclosed |
| US-5481009-A | Methods of producing carboxylic acid ester derivatives and intermediates for use in the methods | FUJIREBIO INC. (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0643054-A2 | Methods of producing carboxylic acid ester derivatives and intermediates for use in the methods | FUJIREBIO Inc. (JP) | 1995-03-15 | — | — | EP | disclosed |