Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | GCGR | P47871 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855427 | 0.84 | HMGCR (0.43) | HMGCRMAP3K11APPCYP2C19FYN | |
| SCHEMBL8854939 | 0.83 | FYN (0.44) | HMGCRMAP3K11FYNCASRP2RX3 | |
| SCHEMBL8855028 | 0.83 | HMGCR (0.42) | HMGCRMAP3K11APPCYP2C19FYN | |
| SCHEMBL8855220 | 0.82 | HMGCR (0.41) | HMGCRMAP3K11APPCYP2C19FYN | |
| SCHEMBL8855082 | 0.82 | HMGCR (0.41) | HMGCRMAP3K11APPCYP2C19FYN | |
| SCHEMBL8855017 | 0.79 | HMGCR (0.45) | HMGCRAPPCYP2C19FYNGCGR | |
| SCHEMBL8855226 | 0.73 | ERN1 (0.45) | HMGCRFYNCASRP2RX3P2RX2 | |
| SCHEMBL8855247 | 0.72 | HMGCR (0.42) | HMGCRMAP3K11FYNCASRP2RX3 | |
| SCHEMBL8855322 | 0.71 | MGAM (0.37) | FYNGCGRMAPK14P2RX3P2RX2 | |
| SCHEMBL8855286 | 0.71 | HMGCR (0.47) | HMGCRCYP2C19PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599952-A | A 4-FLUOROBIPHENYL DERIVATIVE | FUJIREBIO INC. (JP) | 1997-02-04 | — | — | US | disclosed |
| US-5481009-A | Methods of producing carboxylic acid ester derivatives and intermediates for use in the methods | FUJIREBIO INC. (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0643054-A2 | Methods of producing carboxylic acid ester derivatives and intermediates for use in the methods | FUJIREBIO Inc. (JP) | 1995-03-15 | — | — | EP | disclosed |