Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.31 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856423 | 0.92 | MMP9 (0.35) | MMP9MMP13ADAM17CYSLTR2CYSLTR1 | |
| SCHEMBL8856627 | 0.91 | MMP9 (0.33) | MMP9MMP13ADAM17CYSLTR2CYSLTR1 | |
| SCHEMBL8856259 | 0.90 | EPHX1 (0.34) | MMP9MMP13ADAM17 | |
| SCHEMBL8856916 | 0.83 | MMP9 (0.33) | MMP9MMP13ADAM17CYSLTR2CYSLTR1 | |
| SCHEMBL8856079 | 0.83 | PAK1 (0.34) | MMP9MMP13ADAM17 | |
| SCHEMBL8856159 | 0.83 | PAK1 (0.32) | MMP9MMP13ADAM17 | |
| SCHEMBL8856326 | 0.83 | MMP9 (0.35) | MMP9MMP13ADAM17CYSLTR2CYSLTR1 | |
| SCHEMBL8856162 | 0.82 | MMP9 (0.33) | MMP9MMP13ADAM17PPARG | |
| SCHEMBL8856451 | 0.81 | MMP9 (0.31) | MMP9MMP13ADAM17 | |
| SCHEMBL8856289 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0609960-A1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER INC. (US) | 1994-08-10 | — | — | EP | disclosed |
| WO-1991004027-A1 | NEW N-ARYL AND N-HETEROARYLAMIDE AND UREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A: CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1991-04-04 | — | — | WO | disclosed |