Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 5/20 | 0.38 |
| ▸ | MMP13 | P45452 | 5/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.38 |
| ▸ | MMP1 | P03956 | 4/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856377 | 0.86 | MMP9 (0.38) | MMP9MMP13ADAM17MMP1ALOX5 | |
| SCHEMBL8856326 | 0.86 | MMP9 (0.35) | MMP9MMP13ADAM17MMP1PPARG | |
| SCHEMBL8856916 | 0.85 | MMP9 (0.33) | MMP9MMP13ADAM17MMP1PPARG | |
| SCHEMBL8856159 | 0.85 | PAK1 (0.32) | MMP9MMP13ADAM17MMP1 | |
| SCHEMBL8856079 | 0.85 | PAK1 (0.34) | MMP9MMP13ADAM17 | |
| SCHEMBL8856162 | 0.84 | MMP9 (0.33) | MMP9MMP13ADAM17MMP1ALOX5 | |
| SCHEMBL8856451 | 0.81 | MMP9 (0.31) | MMP9MMP13ADAM17 | |
| SCHEMBL8856289 | 0.81 | — | — | |
| SCHEMBL8856379 | 0.81 | TSHR (0.36) | — | |
| SCHEMBL8856571 | 0.81 | CDC7 (0.36) | MMP9MMP13ADAM17MMP1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |