Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8857605 | 0.92 | HTT (0.50) | HTTUSP2AKR1B10AKR1B1SMN1; SMN2 | |
| SCHEMBL8857315 | 0.89 | PNP (0.49) | HTTUSP2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8857593 | 0.84 | HTT (0.52) | HTTUSP2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8857571 | 0.81 | PNP (0.51) | HTTUSP2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7163122 | 0.80 | HTT (0.53) | HTTUSP2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8857614 | 0.79 | HTT (0.51) | HTTUSP2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8857508 | 0.79 | SMN1; SMN2 (0.51) | HTTUSP2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8857524 | 0.78 | HTT (0.52) | HTTUSP2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8857625 | 0.78 | SMN1; SMN2 (0.52) | HTTUSP2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8857762 | 0.77 | HTT (0.51) | HTTUSP2SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658917-A | ANTIINFLAMMATION AGENT | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-08-19 | — | — | US | disclosed |
| US-5648353-A | INFLAMMATORY EDEMA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-15 | — | — | US | disclosed |
| US-5624926-A | Piperidinyl-dioxoquinazolines as adenosine reuptake inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-04-29 | — | — | US | disclosed |
| US-5605900-A | USEFUL FOR TREATMENT OF INFLAMMATORY EDEMA, ISCHEMIA AND REPERFUSION DISORDERS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| EP-0638567-A1 | ADENOSINE INCORPORATION INHIBITOR | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1995-02-15 | — | — | EP | disclosed |