Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | CTSC | P53634 | 3/20 | 0.52 |
| ▸ | MC4R | P32245 | 2/20 | 0.48 |
| ▸ | MC5R | P33032 | 1/20 | 0.48 |
| ▸ | MC3R | P41968 | 1/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GHSR | Q92847 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL8860168 | 1.00 | KMT2A (0.57) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL9280401 | 0.95 | MEN1 (0.52) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL9280393 | 0.95 | MEN1 (0.52) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL7978129 | 0.94 | KMT2A (0.65) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL7978131 | 0.94 | KMT2A (0.65) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL9220819 | 0.94 | KDM4E (0.65) | KMT2AKDM4EMAPTMEN1LMNA | |
| Methionine SCHEMBL8860166 | 0.93 | MEN1 (0.49) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL9551456 | 0.92 | MEN1 (0.56) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL27344693 | 0.91 | MEN1 (0.48) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL7763177 | 0.90 | KDM4E (0.60) | KMT2AKDM4EMAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597945-A | Plants genetically enhanced for disease resistance | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 1997-01-28 | — | — | US | disclosed |