Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MPO | P05164 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | MC4R | P32245 | 2/20 | 0.55 |
| ▸ | MC5R | P33032 | 1/20 | 0.55 |
| ▸ | MC3R | P41968 | 1/20 | 0.55 |
| ▸ | GHSR | Q92847 | 7/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL9220819 | 0.96 | KDM4E (0.65) | KDM4EMAPTMEN1KMT2ALMNA | |
| Dl-Tryptophan SCHEMBL21219049 | 0.92 | KMT2A (0.71) | KDM4EMAPTMEN1KMT2ALMNA | |
| Tryptophan SCHEMBL2638019 | 0.92 | KDM4E (0.59) | KDM4EMAPTMEN1KMT2ALMNA | |
| Dl-Tryptophan SCHEMBL8860161 | 0.90 | KMT2A (0.57) | KDM4EMAPTMEN1KMT2ALMNA | |
| Tryptophan SCHEMBL8860168 | 0.90 | KMT2A (0.57) | KDM4EMAPTMEN1KMT2ALMNA | |
| Tryptophan SCHEMBL29086840 | 0.90 | KDM4E (0.61) | KDM4EMAPTMEN1KMT2ALMNA | |
| Dl-Tryptophan SCHEMBL27584251 | 0.89 | KDM4E (0.67) | KDM4EMAPTMEN1KMT2ALMNA | |
| D-Tryptophan SCHEMBL8434542 | 0.89 | KDM4E (0.49) | KDM4EMAPTMEN1KMT2ALMNA | |
| D-Tryptophan SCHEMBL8584759 | 0.89 | KDM4E (0.49) | KDM4EMAPTMEN1KMT2ALMNA | |
| Tryptophan SCHEMBL3515219 | 0.88 | KDM4E (0.78) | KDM4EMAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642357-B1 | RADIOLABELLED SOMATOSTATIN | MALLINCKRODT INC (US) | 2001-07-25 | — | — | EP | disclosed |
| EP-1099693-A1 | Radiolabelled peptide compounds | MALLINCKRODT INC. (US) | 2001-05-16 | — | — | EP | disclosed |
| US-5753205-A | Radiolabelled peptide compounds | MALLINCKRODT MEDICAL, INC. (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0642357-A4 | RADIOLABELLED PEPTIDE COMPOUNDS. | — | 1995-04-05 | — | — | EP | disclosed |
| EP-0642357-A1 | RADIOLABELLED PEPTIDE COMPOUNDS | MALLINCKRODT MEDICAL, INC. (US) | 1995-03-15 | — | — | EP | disclosed |
| US-5382654-A | Radionuclide-labled somatostatin | MALLINCKRODT MEDICAL, INC. (US) | 1995-01-17 | — | — | US | disclosed |
| WO-1993015770-A1 | RADIOLABELLED PEPTIDE COMPOUNDS | MALLINCKRODT MEDICAL, INC. (US) | 1993-08-19 | — | — | WO | disclosed |