SCHEMBL8861635

SCHEMBL8861635

Cc1ccc(COC(F)(F)Cc2ccc(OC(F)(F)F)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.49
ACHE P22303 1/20 0.49
MMP12 P39900 1/20 0.42
GRIN2B Q13224 2/20 0.42
ALDH1A1 P00352 1/20 0.41
TSHR P16473 1/20 0.41
CETP P11597 1/20 0.40
SCN10A Q9Y5Y9 1/20 0.40
SLC6A4 P31645 1/20 0.39
AGXT P21549 2/20 0.39
GPR3 P46089 1/20 0.39
CARM1 Q86X55 1/20 0.38
PRMT6 Q96LA8 1/20 0.38
TP53 P04637 1/20 0.38
PTGER4 P35408 1/20 0.38
SCN8A Q9UQD0 1/20 0.37
CASR P41180 1/20 0.37
MAOB P27338 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6664949 0.89 TSHR (0.45) BCHEACHEGRIN2BALDH1A1TSHR
SCHEMBL6666711 0.84 TSHR (0.42) BCHEACHEALDH1A1TSHRSLC6A4
SCHEMBL14437997 0.81 MAOB (0.54) BCHEACHEALDH1A1MAOB
SCHEMBL6663842 0.81 FAAH (0.43) ACHEALDH1A1TSHRSLC6A4TP53
SCHEMBL6667598 0.80 FAAH (0.46) ACHEALDH1A1TSHRSLC6A4TP53
SCHEMBL6664182 0.80 FAAH (0.46) ACHEALDH1A1TSHRSLC6A4TP53
SCHEMBL6667385 0.80 FAAH (0.46) ACHEALDH1A1TSHRSLC6A4TP53
SCHEMBL6662973 0.80 FAAH (0.46) ACHEALDH1A1TSHRSLC6A4TP53
SCHEMBL6666332 0.80 FAAH (0.46) ACHEALDH1A1TSHRSLC6A4TP53
SCHEMBL9061480 0.79 BCHE (0.56) BCHEACHEMMP12GRIN2BALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-9278698-A None JP disclosed
JP-H09278698-A FLUORINE-SUBSTITUTED BOND GROUP-CONTAINING LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY ELEMENT CHISSO CORP 1997-10-28 JP disclosed