Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PRCP | P42785 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9544370 | 0.96 | POLB (0.53) | POLBL3MBTL1MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL9544372 | 0.96 | POLB (0.53) | POLBL3MBTL1MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL15354956 | 0.90 | POLB (0.48) | POLBL3MBTL1MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL7310404 | 0.89 | POLB (0.62) | POLBL3MBTL1ALDH1A1TSHRPSEN1 | |
| SCHEMBL8482480 | 0.89 | POLB (0.62) | POLBL3MBTL1ALDH1A1TSHRPSEN1 | |
| SCHEMBL8477564 | 0.89 | POLB (0.62) | POLBL3MBTL1ALDH1A1TSHRPSEN1 | |
| SCHEMBL8477698 | 0.89 | POLB (0.62) | POLBL3MBTL1ALDH1A1TSHRPSEN1 | |
| SCHEMBL8477557 | 0.89 | POLB (0.62) | POLBL3MBTL1ALDH1A1TSHRPSEN1 | |
| SCHEMBL8477697 | 0.89 | POLB (0.62) | POLBL3MBTL1ALDH1A1TSHRPSEN1 | |
| SCHEMBL23485199 | 0.88 | POLB (0.61) | POLBALDH1A1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130065935-A1 | Novel Inhibitors of the Amino Acid Transporters ASCT1 and ASCT2 | THE UNIVERSITY OF MONTANA | 2013-03-14 | — | — | US | disclosed |
| US-5631385-A | Method for the preparation of N-substituted 4-ketoproline derivatives | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1997-05-20 | — | — | US | disclosed |
| EP-0752419-A2 | Process for the preparation of N-substituted 4-ketoproline derivatives | Degussa Aktiengesellschaft (DE) | 1997-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065935-A1 | Novel Inhibitors of the Amino Acid Transporters ASCT1 and ASCT2 | SLC1A2, SLC1A1, SLC1A3 | POLB 3030/4885L3MBTL1 317/4885MAPK1 2475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.