Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9058164 | 0.96 | CHRM1 (0.58) | HSD11B1CHRM1OPRM1TNKSPARP1 | |
| SCHEMBL8863920 | 0.90 | CHRM1 (0.54) | HSD11B1CHRM1OPRM1CHRM2CHRM4 | |
| SCHEMBL8863918 | 0.88 | CHRM1 (0.66) | HSD11B1CHRM1OPRM1TNKSPARP1 | |
| SCHEMBL8863851 | 0.88 | CHRM1 (0.54) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL8863532 | 0.87 | CHRM1 (0.60) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL8863625 | 0.86 | CHRM1 (0.76) | HSD11B1CHRM1OPRM1 | |
| SCHEMBL8863533 | 0.86 | HSD11B1 (0.61) | HSD11B1CHRM1OPRM1 | |
| SCHEMBL8863373 | 0.85 | CHRM1 (0.57) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL8863412 | 0.85 | CHRM1 (0.57) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL8863917 | 0.85 | CHRM1 (0.56) | HSD11B1CHRM1CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996013262-A1 | MUSCARINE ANTAGONISTS | MERCK & CO., INC. (US) | 1996-05-09 | — | — | WO | claimed |
| US-5691323-A | BENZIMIDAZOL-2-ONES | MERCK & CO., INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5574044-A | BENZIMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF MYOPIA | MERCK & CO., INC. (US) | 1996-11-12 | — | — | US | disclosed |
| WO-1996013262-A1 | MUSCARINE ANTAGONISTS | MERCK & CO., INC. (US) | 1996-05-09 | — | — | WO | disclosed |