Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.78 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.77 |
| ▸ | MET | P08581 | 4/20 | 0.77 |
| ▸ | INSR | P06213 | 8/20 | 0.72 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.72 |
| ▸ | IGF1R | P08069 | 2/20 | 0.72 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.72 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.72 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.72 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.72 |
| ▸ | EGFR | P00533 | 2/20 | 0.72 |
| ▸ | CDC7 | O00311 | 1/20 | 0.72 |
| ▸ | PLK4 | O00444 | 1/20 | 0.72 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.72 |
| ▸ | AURKA | O14965 | 1/20 | 0.72 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.72 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.72 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.72 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.72 |
| ▸ | JAK2 | O60674 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885670 | 0.92 | MAP4K1 (0.80) | MAP4K1ALKMETINSRPTK2 | |
| SCHEMBL885927 | 0.91 | MAP4K1 (0.80) | MAP4K1ALKMETINSRPTK2 | |
| SCHEMBL884863 | 0.91 | MAP4K1 (0.67) | MAP4K1ALKMETINSRPTK2 | |
| SCHEMBL886481 | 0.89 | MAP4K1 (0.78) | MAP4K1ALKMETINSRPTK2 | |
| SCHEMBL886527 | 0.88 | MAP4K1 (0.76) | MAP4K1ALKMETINSRPTK2 | |
| SCHEMBL20214583 | 0.88 | MAP4K1 (1.00) | MAP4K1ALKMETINSRPTK2 | |
| SCHEMBL885707 | 0.87 | ALK (0.83) | MAP4K1ALKMETINSRPTK2 | |
| SCHEMBL886512 | 0.87 | MAP4K1 (0.75) | MAP4K1ALKMETINSRPTK2 | |
| SCHEMBL886744 | 0.84 | MAP4K1 (0.69) | MAP4K1ALKMETINSRPTK2 | |
| SCHEMBL886431 | 0.84 | MAP4K1 (0.74) | MAP4K1ALKMETINSRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684874-B1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | CEPHALON INC (US) | 2017-05-17 | — | — | EP | claimed |
| EP-2222647-B1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2015-08-05 | — | — | EP | claimed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | claimed |
| US-20090221555-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS | CEPHALON, INC. (US) | 2009-09-03 | — | — | US | claimed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | claimed |
| EP-2684874-B1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | CEPHALON INC (US) | 2017-05-17 | — | — | EP | disclosed |
| EP-2222647-B1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2015-08-05 | — | — | EP | disclosed |
| EP-2684874-A1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | Cephalon, Inc. (US) | 2014-01-15 | — | — | EP | disclosed |
| US-8552186-B2 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-MET inhibitors | CEPHALON, INC. (US) | 2013-10-08 | — | — | US | disclosed |
| US-20120165519-A1 | Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors | CEPHALON, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-8148391-B2 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors | CEPHALON, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20090221555-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS | CEPHALON, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221555-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS | ALK, MET, RET | MAP4K1 325/4885ALK 1/4885MET 2/4885 |
| US-20120165519-A1 | Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors | ALK, MET, RET | MAP4K1 325/4885ALK 1/4885MET 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.