SCHEMBL88648 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	TUBB1	Q9H4B7	2/20	0.57

▸	POLB	P06746	1/20	0.33

▸	MMP1	P03956	2/20	0.32

▸	MMP3	P08254	1/20	0.32

▸	MMP9	P14780	1/20	0.32

▸	MMP8	P22894	1/20	0.32

▸	STAT6	P42226	2/20	0.32

▸	ADAM17	P78536	1/20	0.30

▸	CTSL	P07711	1/20	0.30

▸	CTSB	P07858	1/20	0.30

▸	CTSS	P25774	1/20	0.30

▸	CTSK	P43235	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL13848967	1.00	TUBB1 (0.57)	TUBB1POLBMMP1MMP3MMP9
SCHEMBL88728	1.00	TUBB1 (0.57)	TUBB1POLBMMP1MMP3MMP9
SCHEMBL57419	1.00	TUBB1 (0.57)	TUBB1POLBMMP1MMP3MMP9
SCHEMBL14233245	0.92	TUBB1 (0.62)	TUBB1MMP1MMP3MMP9MMP8
SCHEMBL57221	0.91	TUBB1 (0.62)	TUBB1MMP1MMP3MMP9MMP8
SCHEMBL89243	0.91	TUBB1 (0.62)	TUBB1MMP1MMP3MMP9MMP8
SCHEMBL13682604	0.91	TUBB1 (0.62)	TUBB1MMP1MMP3MMP9MMP8
SCHEMBL13848969	0.91	TUBB1 (0.62)	TUBB1MMP1MMP3MMP9MMP8
SCHEMBL88936	0.87	TUBB1 (0.60)	TUBB1MMP1MMP3MMP9MMP8
SCHEMBL14233799	0.87	TUBB1 (0.60)	TUBB1MMP1MMP3MMP9MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-8633224-B2	Hemiasterlin derivatives and uses thereof in the treatment of cancer	EISAI CO., LTD. (JP)	2014-01-21	—	—	US	disclosed