Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.57 |
| ▸ | INSR | P06213 | 13/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL886533 | 0.95 | MET (0.55) | METINSRALK | |
| SCHEMBL16966168 | 0.87 | MET (0.50) | METINSRALK | |
| SCHEMBL886277 | 0.86 | MET (0.53) | METINSRALK | |
| SCHEMBL886148 | 0.85 | MET (0.78) | METINSR | |
| SCHEMBL886426 | 0.84 | MET (0.72) | METINSRALK | |
| SCHEMBL2062756 | 0.82 | MET (0.56) | METINSRALK | |
| SCHEMBL886626 | 0.82 | MET (0.52) | METINSRALK | |
| SCHEMBL16966051 | 0.82 | MET (0.48) | METINSRALK | |
| SCHEMBL886502 | 0.82 | MET (0.71) | METINSRALK | |
| SCHEMBL886518 | 0.82 | MET (0.69) | METINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684874-B1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | CEPHALON INC (US) | 2017-05-17 | — | — | EP | claimed |
| EP-2222647-B1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2015-08-05 | — | — | EP | claimed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | claimed |
| US-20090221555-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS | CEPHALON, INC. (US) | 2009-09-03 | — | — | US | claimed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | claimed |
| EP-2684874-B1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | CEPHALON INC (US) | 2017-05-17 | — | — | EP | disclosed |
| EP-2222647-B1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2015-08-05 | — | — | EP | disclosed |
| EP-2684874-A1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | Cephalon, Inc. (US) | 2014-01-15 | — | — | EP | disclosed |
| US-8552186-B2 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-MET inhibitors | CEPHALON, INC. (US) | 2013-10-08 | — | — | US | disclosed |
| EP-2182088-B1 | Atomic layer deposition using metal amidinates | HARVARD COLLEGE (US) | 2013-07-17 | — | — | EP | disclosed |
| US-8455672-B2 | Atomic layer deposition using metal amidinates | PRESIDENT AND FELLOWS OF HARVARD (US) | 2013-06-04 | — | — | US | disclosed |
| US-20120165519-A1 | Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors | CEPHALON, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-7557229-B2 | Atomic layer deposition using metal amidinates | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-07-07 | — | — | US | disclosed |
| EP-1688426-B1 | Organometallic complexes and their use as precursors to deposit metal films | AIR PROD & CHEM (US) | 2008-07-23 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |
| EP-1688426-A1 | Organometallic complexes and their use as precursors to deposit metal films | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2006-08-09 | — | — | EP | disclosed |
| US-20060141155-A1 | Atomic layer deposition using metal amidinates | HAVARD UNIVERSITY | 2006-06-29 | — | — | US | disclosed |
| US-7064224-B1 | Organometallic complexes and their use as precursors to deposit metal films | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2006-06-20 | — | — | US | disclosed |
| EP-1563117-A2 | ATOMIC LAYER DEPOSITION USING METAL AMIDINATES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004046417-A2 | ATOMIC LAYER DEPOSITION USING METAL AMIDINATES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221555-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS | ALK, MET, RET | MET 2/4885INSR 241/4885ALK 1/4885 |
| US-20120165519-A1 | Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors | ALK, MET, RET | MET 2/4885INSR 241/4885ALK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.