Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 6/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8865510 | 1.00 | NPC1 (0.48) | NPC1RAB9AKDM4EALDH1A1HTT | |
| SCHEMBL8864815 | 0.88 | ALOX5 (0.51) | NPC1RAB9AKDM4EALDH1A1KMT2A | |
| SCHEMBL8864827 | 0.88 | ALOX5 (0.51) | NPC1RAB9AKDM4EALDH1A1KMT2A | |
| SCHEMBL8865614 | 0.84 | GSK3B (0.50) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL8865604 | 0.84 | GSK3B (0.50) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL8415544 | 0.82 | AKR1C3 (0.56) | NPC1RAB9AKDM4EALDH1A1HTT | |
| SCHEMBL4579188 | 0.82 | AKR1C3 (0.56) | NPC1RAB9AKDM4EALDH1A1HTT | |
| SCHEMBL11250951 | 0.80 | NR1H4 (0.55) | NPC1RAB9AKDM4EALDH1A1HTT | |
| SCHEMBL8865036 | 0.80 | MAPT (0.44) | NPC1RAB9AKDM4EALDH1A1HTT | |
| SCHEMBL8865053 | 0.80 | MAPT (0.44) | NPC1RAB9AKDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646313-A | PREPARING ENKEPHALINASE INHIBITORS | SOCIETE CIVILE BIOPROJET (FR) | 1997-07-08 | — | — | US | disclosed |
| US-5612371-A | ENZYME INHIBITORS | SOCIETE CIVILE BIOPROJECT (FR) | 1997-03-18 | — | — | US | disclosed |