Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 19/20 | 1.00 |
| ▸ | ABCC8 | Q09428 | 19/20 | 1.00 |
| ▸ | KCNJ11 | Q14654 | 19/20 | 1.00 |
| ▸ | KCNJ8 | Q15842 | 19/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8866922 | 0.86 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL8866056 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL8866846 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL8866620 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL2128828 | 0.83 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL8866396 | 0.83 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL7711839 | 0.82 | ABCC9 (0.70) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL4608644 | 0.82 | ABCC9 (0.70) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8866328 | 0.81 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL8865688 | 0.80 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684198-A | N-ARYL-2-HYDROXYPROPANAMIDES | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1997-11-04 | — | — | US | disclosed |
| US-5567735-A | CELL POTASSIUM CHANNEL MODULATOR FOR TREATING ASTHMA | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-10-22 | — | — | US | disclosed |
| US-5565477-A | TREATMENT OF URINARY INCONTINENCE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-10-15 | — | — | US | disclosed |
| US-5565465-A | TREATMENT OF URINARY INCONTINENCE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-10-15 | — | — | US | disclosed |
| EP-0524781-B1 | Therapeutic amides | ZENECA LTD (GB) | 1996-03-27 | — | — | EP | disclosed |
| US-5474999-A | Useful in treatment of urinary incontinence | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-12-12 | — | — | US | disclosed |
| US-5382598-A | Therapeutic amides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-01-17 | — | — | US | disclosed |
| US-5272163-A | Therapeutic amides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-21 | — | — | US | disclosed |
| EP-0524781-A1 | Therapeutic amides | ZENECA LIMITED (GB) | 1993-01-27 | — | — | EP | disclosed |