Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22493741 | 0.80 | PLAU (0.46) | PLAU | |
| SCHEMBL8865864 | 0.79 | PLAU (0.43) | PLAUKDM4ESMN1; SMN2 | |
| SCHEMBL23706067 | 0.77 | PLAU (0.43) | PLAU | |
| SCHEMBL31091988 | 0.77 | PLAU (0.43) | PLAU | |
| SCHEMBL31168516 | 0.75 | S100A9 (0.38) | PLAUCYP11B1CYP11B2KCNJ5KCNJ3 | |
| SCHEMBL31168519 | 0.75 | S100A9 (0.38) | PLAUCYP11B1CYP11B2KCNJ5KCNJ3 | |
| SCHEMBL20188949 | 0.74 | PLAU (0.43) | PLAUSMN1; SMN2 | |
| SCHEMBL25224414 | 0.74 | PLAU (0.43) | PLAUSMN1; SMN2 | |
| SCHEMBL30481308 | 0.74 | PLAU (0.43) | PLAUSMN1; SMN2 | |
| SCHEMBL19534297 | 0.72 | PLAU (0.46) | PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436344-A | 3-bromo-5-chloro-pyridines used as intermediates in the synthesis of azatetralones | PFIZER INC. (US) | 1995-07-25 | — | — | US | claimed |
| US-5677458-A | Method of preparing azatetralones | PFIZER INC. (US) | 1997-10-14 | — | — | US | disclosed |
| US-5608071-A | Synthesis of 3-bromo-5-chloro-2-alkyl-pyridine derivatives | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| US-5436344-A | 3-bromo-5-chloro-pyridines used as intermediates in the synthesis of azatetralones | PFIZER INC. (US) | 1995-07-25 | — | — | US | disclosed |