Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.43 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 3/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3939229 | 0.81 | AGBL2 (0.43) | PLAULMNAL3MBTL1MAPK8TBXAS1 | |
| SCHEMBL29009825 | 0.81 | AGBL2 (0.46) | LMNAHDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL8866071 | 0.79 | PLAU (0.40) | PLAUSMN1; SMN2KDM4E | |
| SCHEMBL22493741 | 0.72 | PLAU (0.46) | PLAULMNAL3MBTL1 | |
| SCHEMBL29009968 | 0.72 | GPR17 (0.38) | HDAC3MAPK1ADRA1AHDAC4SLC6A3 | |
| SCHEMBL23705809 | 0.72 | PLAU (0.43) | PLAULMNAL3MBTL1THRATHRB | |
| SCHEMBL30042575 | 0.72 | PLAU (0.43) | PLAULMNAL3MBTL1THRATHRB | |
| SCHEMBL20188949 | 0.70 | PLAU (0.43) | PLAULMNASMN1; SMN2 | |
| SCHEMBL30481308 | 0.70 | PLAU (0.43) | PLAULMNASMN1; SMN2 | |
| SCHEMBL25224414 | 0.70 | PLAU (0.43) | PLAULMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436344-A | 3-bromo-5-chloro-pyridines used as intermediates in the synthesis of azatetralones | PFIZER INC. (US) | 1995-07-25 | — | — | US | claimed |
| US-5677458-A | Method of preparing azatetralones | PFIZER INC. (US) | 1997-10-14 | — | — | US | disclosed |
| US-5608071-A | Synthesis of 3-bromo-5-chloro-2-alkyl-pyridine derivatives | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| US-5436344-A | 3-bromo-5-chloro-pyridines used as intermediates in the synthesis of azatetralones | PFIZER INC. (US) | 1995-07-25 | — | — | US | disclosed |