Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8866212 | 0.97 | KMT2A (0.48) | KMT2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8867236 | 0.83 | KMT2A (0.47) | KMT2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8866451 | 0.81 | KMT2A (0.43) | KMT2A | |
| SCHEMBL8866456 | 0.81 | KMT2A (0.43) | KMT2A | |
| SCHEMBL13363110 | 0.79 | — | — | |
| Ethylene SCHEMBL9699905 | 0.75 | — | — | |
| SCHEMBL8866529 | 0.75 | ALDH1A1 (0.32) | ALDH1A1L3MBTL1 | |
| SCHEMBL10339106 | 0.74 | KMT2A (0.49) | KMT2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL9253158 | 0.73 | KMT2A (0.41) | KMT2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL138832 | 0.72 | KMT2A (0.50) | KMT2AALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594000-A | THAT STIMULATE CENTRAL MUSCARINIC ACETYLCHOLINE RECEPTORS, ANALGESICS, NERVOUS SYSTEM DISORDERS, MENTAL ILLNESS | ASTRA AB (SE) | 1997-01-14 | — | — | US | disclosed |
| WO-1994000456-A1 | SPIROFURANE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS | FISONS CORPORATION (US) | 1994-01-06 | — | — | WO | disclosed |
| EP-0491562-A1 | Novel spirofurane derivatives | FISONS CORPORATION (US) | 1992-06-24 | — | — | EP | disclosed |