Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27862967 | 0.82 | TSHR (0.57) | TSHRHTTALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL30071543 | 0.82 | TSHR (0.57) | TSHRHTTALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL25780705 | 0.80 | TSHR (0.58) | TSHRHTTALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL7360724 | 0.79 | TSHR (0.57) | TSHRALDH1A1HSD17B10KDM4ELMNA | |
| SCHEMBL17141443 | 0.79 | PARP1 (0.45) | HTTALDH1A1NUDT1HSD17B10KDM4E | |
| SCHEMBL31657672 | 0.79 | PARP1 (0.45) | HTTALDH1A1NUDT1HSD17B10KDM4E | |
| SCHEMBL8867433 | 0.79 | KDM4E (0.61) | TSHRHTTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL14840570 | 0.78 | TSHR (0.49) | TSHRHTTALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL21663913 | 0.77 | TSHR (0.47) | TSHRHTTALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL17793834 | 0.77 | JMJD6 (0.59) | TSHRHTTALDH1A1HSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670456-A | Compounds | SANDOZ LTD. (CH) | 1997-09-23 | — | — | US | disclosed |
| US-5506191-A | Heterocyclic hydrazines and hydrazones | SANDOZ LTD. (CH) | 1996-04-09 | — | — | US | disclosed |