Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 3/20 | 0.49 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3615192 | 0.92 | SMN1; SMN2 (0.68) | SMN1; SMN2ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL8866740 | 0.90 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL3434172 | 0.87 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL8867138 | 0.86 | CDC7 (0.62) | SMN1; SMN2ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL1327631 | 0.84 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL23794689 | 0.84 | KMT2A (0.80) | SMN1; SMN2ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL3436646 | 0.84 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL12582103 | 0.84 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL289112 | 0.81 | SMN1; SMN2 (0.93) | SMN1; SMN2ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL8867051 | 0.81 | RAB9A (0.79) | SMN1; SMN2ALDH1A1RAB9AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614520-A | 2-arylthiazole derivatives and pharmaceutical composition thereof | TEIJIN LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0513379-B1 | 2-ARYLTHIAZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | TEIJIN LTD (JP) | 1996-09-11 | — | — | EP | disclosed |
| EP-0513379-A1 | 2-ARYLTHIAZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | TEIJIN LIMITED (JP) | 1992-11-19 | — | — | EP | disclosed |