Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2062839 | 0.85 | MKNK1 (0.43) | KCNA5MKNK1MKNK2JAK2JAK3 | |
| SCHEMBL885805 | 0.82 | KCNA5 (0.41) | KCNA5MKNK1MKNK2KCNH2 | |
| SCHEMBL884468 | 0.82 | KCNA5 (0.79) | KCNA5CYP19A1KCNH2GBA1 | |
| SCHEMBL2063123 | 0.78 | KCNA5 (0.82) | KCNA5KCNH2 | |
| SCHEMBL885991 | 0.76 | KCNA5 (0.49) | KCNA5MKNK1MKNK2KCNH2 | |
| SCHEMBL884895 | 0.75 | KCNA5 (0.82) | KCNA5KCNH2 | |
| SCHEMBL884617 | 0.74 | KCNA5 (0.95) | KCNA5KCNH2 | |
| SCHEMBL884806 | 0.73 | KCNA5 (1.00) | KCNA5KCNH2 | |
| SCHEMBL884927 | 0.72 | KCNA5 (0.46) | KCNA5KCNH2 | |
| SCHEMBL884928 | 0.72 | KCNA5 (0.46) | KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |