Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869545 | 0.95 | CA1 (0.54) | TSHRALDH1A1CA1CA2CA7 | |
| SCHEMBL8868956 | 0.94 | TSHR (0.53) | TSHRALDH1A1CA1CA2CA7 | |
| SCHEMBL8868124 | 0.94 | TSHR (0.58) | TSHRALDH1A1CA1CA2CA7 | |
| SCHEMBL8868428 | 0.92 | CNR2 (0.54) | TSHRALDH1A1CA1CA2CA7 | |
| SCHEMBL8868966 | 0.90 | TSHR (0.58) | TSHRALDH1A1CA1CA2CA7 | |
| SCHEMBL8868437 | 0.90 | TSHR (0.52) | TSHRALDH1A1CA1CA2CA7 | |
| SCHEMBL8868963 | 0.90 | TSHR (0.54) | TSHRALDH1A1CA1CA2CA7 | |
| SCHEMBL8869027 | 0.90 | P4HTM (0.55) | TSHRALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL8868857 | 0.89 | TSHR (0.61) | TSHRALDH1A1CA1CA2CA7 | |
| SCHEMBL8869492 | 0.89 | CA1 (0.53) | TSHRALDH1A1CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |