Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.40 |
| ▸ | BCL2 | P10415 | 3/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8867875 | 0.90 | P4HTM (0.47) | P4HTMALDH1A1NTRK2BCL2L1BCL2 | |
| SCHEMBL9141161 | 0.89 | P4HTM (0.59) | P4HTMALDH1A1HPGDBCL2L1BCL2 | |
| SCHEMBL8868581 | 0.89 | P4HTM (0.43) | P4HTMALDH1A1HPGDBCL2L1BCL2 | |
| SCHEMBL8868877 | 0.88 | SMN1; SMN2 (0.50) | P4HTMBCL2L1FBP1MCL1CYP2C19 | |
| SCHEMBL9140272 | 0.87 | P4HTM (0.47) | P4HTMALDH1A1HPGDBCL2L1BCL2 | |
| SCHEMBL7862880 | 0.87 | P4HTM (0.37) | P4HTMALDH1A1HPGDNTRK2BCL2L1 | |
| SCHEMBL8868684 | 0.86 | P4HTM (0.47) | P4HTMBCL2L1FBP1MCL1HSD17B10 | |
| SCHEMBL9517927 | 0.85 | P4HTM (0.42) | P4HTMALDH1A1HPGDBCL2L1BCL2 | |
| SCHEMBL9139242 | 0.85 | P4HTM (0.44) | P4HTMALDH1A1HPGDBCL2L1BCL2 | |
| SCHEMBL9139237 | 0.85 | P4HTM (0.44) | P4HTMALDH1A1HPGDBCL2L1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |