Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 1/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2837501 | 0.83 | ACP1 (0.65) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL2837504 | 0.83 | ACP1 (0.65) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL308139 | 0.81 | ACP1 (0.63) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL27791809 | 0.81 | ACP1 (0.63) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL11312790 | 0.81 | ACP1 (0.63) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL3076122 | 0.81 | ACP1 (0.63) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL15480444 | 0.81 | ALDH1A1 (0.68) | ACP1HSD17B10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1358344 | 0.81 | ACP1 (0.63) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL175217 | 0.81 | ADORA2A (0.68) | ACP1EPHX2HSD17B10RAB9ANPC1 | |
| SCHEMBL479906 | 0.81 | ACP1 (0.63) | ACP1EPHX2HSD17B10RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1308071-A | Bicyclic DNA gyrase inhibitor | HOFFMANN LA ROCHE (CH) | 2001-08-15 | — | — | CN | disclosed |
| US-5665746-A | BACTERICIDE | HOFFMANN-LA ROCHE INC. (US) | 1997-09-09 | — | — | US | disclosed |
| US-5594135-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1997-01-14 | — | — | US | disclosed |
| US-5589473-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1996-12-31 | — | — | US | disclosed |
| EP-0535192-B1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | HOFFMANN LA ROCHE (CH) | 1996-06-19 | — | — | EP | disclosed |
| US-5486466-A | ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-01-23 | — | — | US | disclosed |
| EP-0675122-A2 | Mono or bicyclic DNA gyrase inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-04 | — | — | EP | disclosed |
| US-5399741-A | DNA gyrase inhibitors, process for their manufacture and pharmaceutical preparations containing same | HOFFMANN-LA ROCHE INC. (US) | 1995-03-21 | — | — | US | disclosed |
| US-5294609-A | Microbiocides | HOFFMANN-LAROCHE INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0535192-A1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME. | HOFFMANN LA ROCHE (CH) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992018490-A1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | F. HOFFMANN-LA ROCHE AG (CH) | 1992-10-29 | — | — | WO | disclosed |