Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868623 | 0.92 | EPHX2 (0.47) | EPHX2LMNAMAPTCYP3A4CYP2C9 | |
| SCHEMBL8869358 | 0.92 | EPHX2 (0.43) | EPHX2LMNAMAPTCYP3A4CYP2C9 | |
| SCHEMBL9139947 | 0.91 | EPHX2 (0.46) | EPHX2LMNAMAPTCYP3A4CYP2C9 | |
| SCHEMBL8869510 | 0.91 | LMNA (0.52) | EPHX2LMNAMAPTCYP3A4CYP2C9 | |
| SCHEMBL8869208 | 0.89 | MAPT (0.45) | EPHX2LMNAMAPTCYP3A4CYP2C9 | |
| SCHEMBL9139607 | 0.89 | P4HTM (0.53) | EPHX2LMNAMAPTCYP3A4CYP2C9 | |
| SCHEMBL7862673 | 0.89 | EPHX2 (0.44) | EPHX2LMNAMAPTCYP3A4CYP2C9 | |
| SCHEMBL8869596 | 0.86 | CA1 (0.43) | LMNAMAPTSMN1; SMN2P4HTMALDH1A1 | |
| SCHEMBL8869814 | 0.86 | P4HTM (0.48) | LMNAMAPTSMN1; SMN2P4HTMALDH1A1 | |
| SCHEMBL8869241 | 0.85 | P4HTM (0.46) | LMNAMAPTSMN1; SMN2P4HTMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |