Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.44 |
| ▸ | USP5 | P45974 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869573 | 0.91 | MAPT (0.56) | MAPTTSHRLMNACYP3A4HTR1A | |
| SCHEMBL9140536 | 0.91 | P4HTM (0.55) | MAPTTSHRLMNACYP3A4HTR1A | |
| SCHEMBL8867649 | 0.91 | MAPT (0.53) | MAPTTSHRLMNACYP3A4HTR1A | |
| SCHEMBL8868512 | 0.88 | MAPT (0.47) | MAPTTSHRLMNACYP3A4HTR1A | |
| SCHEMBL8869656 | 0.88 | MAPT (0.56) | MAPTTSHRLMNACYP3A4HTR1A | |
| SCHEMBL8868281 | 0.88 | LMNA (0.49) | MAPTTSHRLMNACYP3A4HTR1A | |
| SCHEMBL8869180 | 0.88 | TSHR (0.50) | MAPTTSHRLMNACYP3A4HTR1A | |
| SCHEMBL9141318 | 0.87 | MAPT (0.54) | MAPTTSHRLMNACYP3A4HTR1A | |
| SCHEMBL8868905 | 0.86 | MAPT (0.53) | MAPTTSHRLMNACYP3A4HTR1A | |
| SCHEMBL9137083 | 0.84 | TSHR (0.51) | MAPTTSHRLMNACYP3A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |