Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.53 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9138505 | 0.93 | P4HTM (0.62) | RAB9AP4HTMNPC1SMN1; SMN2HPGD | |
| SCHEMBL8870376 | 0.91 | RAB9A (0.52) | RAB9AP4HTMNPC1SMN1; SMN2HPGD | |
| SCHEMBL8869710 | 0.91 | P4HTM (0.56) | RAB9AP4HTMNPC1SMN1; SMN2HPGD | |
| SCHEMBL8869820 | 0.90 | RAB9A (0.51) | RAB9AP4HTMNPC1SMN1; SMN2HPGD | |
| SCHEMBL9139840 | 0.90 | RAB9A (0.54) | RAB9AP4HTMNPC1SMN1; SMN2HPGD | |
| SCHEMBL8869595 | 0.90 | P4HTM (0.49) | RAB9AP4HTMHPGDTP53 | |
| SCHEMBL7870551 | 0.89 | RAB9A (0.49) | RAB9AP4HTMNPC1SMN1; SMN2HPGD | |
| SCHEMBL9143465 | 0.88 | RAB9A (0.53) | RAB9AP4HTMNPC1SMN1; SMN2HPGD | |
| SCHEMBL8870268 | 0.88 | P4HTM (0.47) | RAB9AP4HTMHPGD | |
| SCHEMBL8869265 | 0.87 | P4HTM (0.47) | RAB9AP4HTMBCL2L1MCL1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |