Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869137 | 1.00 | TBXA2R (0.43) | TBXA2RCA2TMEM97SIGMAR1ALOX5 | |
| SCHEMBL29060379 | 0.95 | TBXA2R (0.42) | TBXA2RCA2TMEM97SIGMAR1ALOX5 | |
| SCHEMBL10309083 | 0.95 | TBXA2R (0.42) | TBXA2RCA2TMEM97SIGMAR1ALOX5 | |
| SCHEMBL15198688 | 0.93 | TBXA2R (0.41) | TBXA2RCA2TMEM97SIGMAR1ALOX5 | |
| SCHEMBL7154220 | 0.89 | CA2 (0.44) | TBXA2RCA2TMEM97SIGMAR1UGT2B7 | |
| SCHEMBL7157022 | 0.89 | CA2 (0.44) | TBXA2RCA2TMEM97SIGMAR1UGT2B7 | |
| SCHEMBL5316548 | 0.89 | CA2 (0.44) | TBXA2RCA2TMEM97SIGMAR1UGT2B7 | |
| SCHEMBL6521316 | 0.83 | CA2 (0.41) | TBXA2RCA2TMEM97SIGMAR1TBXAS1 | |
| SCHEMBL24326321 | 0.82 | TSHR (0.42) | CA2TMEM97SIGMAR1ALDH1A1NPSR1 | |
| SCHEMBL1842907 | 0.82 | TSHR (0.42) | CA2TMEM97SIGMAR1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1308071-A | Bicyclic DNA gyrase inhibitor | HOFFMANN LA ROCHE (CH) | 2001-08-15 | — | — | CN | disclosed |
| US-5665746-A | BACTERICIDE | HOFFMANN-LA ROCHE INC. (US) | 1997-09-09 | — | — | US | disclosed |
| US-5594135-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1997-01-14 | — | — | US | disclosed |
| US-5589473-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1996-12-31 | — | — | US | disclosed |
| CN-1114648-A | Novel monocyclic and bicyclic DNA gyrase inhibitors | HOFFMANN LA ROCHE (CH) | 1996-01-10 | — | — | CN | disclosed |
| EP-0675122-A2 | Mono or bicyclic DNA gyrase inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-04 | — | — | EP | disclosed |