Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 6/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869549 | 0.94 | P4HTM (0.50) | P4HTMGABRA5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8868598 | 0.90 | P4HTM (0.51) | P4HTMNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8869393 | 0.89 | P4HTM (0.63) | P4HTMNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9140452 | 0.88 | P4HTM (0.53) | P4HTMGABRA5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8868409 | 0.87 | P4HTM (0.50) | P4HTMGABRA5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8870311 | 0.87 | P4HTM (0.46) | P4HTMGABRA5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8869623 | 0.86 | P4HTM (0.49) | P4HTMGABRA5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8867592 | 0.85 | P4HTM (0.57) | P4HTMNPC1RAB9ASMN1; SMN2PTPN1 | |
| SCHEMBL9140278 | 0.85 | P4HTM (0.52) | P4HTMGABRA5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8870177 | 0.85 | KMT2A (0.46) | P4HTMNPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |