Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868431 | 0.94 | KMT2A (0.43) | KMT2AMEN1P4HTMMMP8MMP12 | |
| SCHEMBL8869549 | 0.90 | P4HTM (0.50) | KMT2AMEN1P4HTMMMP8MMP12 | |
| SCHEMBL9140185 | 0.88 | P4HTM (0.48) | KMT2AMEN1P4HTMMMP8MMP12 | |
| SCHEMBL8869544 | 0.88 | ALDH1A1 (0.49) | KMT2AMEN1P4HTMMMP8MMP12 | |
| SCHEMBL8868434 | 0.87 | KMT2A (0.45) | KMT2AMEN1P4HTMMMP8MMP12 | |
| SCHEMBL8870184 | 0.86 | KMT2A (0.46) | KMT2AMEN1P4HTMMMP8MMP12 | |
| SCHEMBL8869538 | 0.85 | KMT2A (0.55) | KMT2AMEN1P4HTMMMP8MMP12 | |
| SCHEMBL8869220 | 0.85 | P4HTM (0.54) | KMT2AMEN1P4HTMALDH1A1GAA | |
| SCHEMBL8869618 | 0.85 | P4HTM (0.48) | KMT2AMEN1P4HTMPOLBRAB9A | |
| SCHEMBL8867821 | 0.84 | CXCR1 (0.40) | KMT2AMEN1P4HTMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |