⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12562212 | 0.74 | FBP1 (0.38) | — | |
| SCHEMBL28715877 | 0.71 | — | — | |
| SCHEMBL609864 | 0.69 | — | — | |
| SCHEMBL21546027 | 0.69 | — | — | |
| SCHEMBL609158 | 0.65 | — | — | |
| SCHEMBL6156892 | 0.65 | — | — | |
| SCHEMBL29280264 | 0.65 | FBP1 (0.32) | — | |
| SCHEMBL9693201 | 0.65 | FBP1 (0.42) | — | |
| SCHEMBL745693 | 0.63 | FBP1 (0.31) | — | |
| SCHEMBL29712319 | 0.61 | TDP1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103534258-B | Tyrosine kinase inhibitor | 普林斯匹亚生物制药公司 | 2016-09-14 | — | — | CN | claimed |
| CN-109790153-A | Plant with increased herbicide tolerant | 巴斯夫农业公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-109415363-A | For treating the new mitochondrial uncoupler of metabolic disease and cancer | 罗格斯，新泽西州立大学 | 2019-03-01 | — | — | CN | disclosed |
| CN-105102452-B | The ketones derivant of 5 (base of 3,5 dimethyl isoxazole 4) indoline 2 of substitution | 百济神州有限公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-104936957-B | Certain dipeptidyl peptidase inhibitors | 重庆复创医药研究有限公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-104884458-B | fused heterocyclic compounds as protein kinase inhibitors | 百济神州有限公司 | 2017-04-12 | — | — | CN | disclosed |
| CN-1308071-A | Bicyclic DNA gyrase inhibitor | HOFFMANN LA ROCHE (CH) | 2001-08-15 | — | — | CN | disclosed |
| US-5665746-A | BACTERICIDE | HOFFMANN-LA ROCHE INC. (US) | 1997-09-09 | — | — | US | disclosed |
| US-5594135-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1997-01-14 | — | — | US | disclosed |
| US-5589473-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1996-12-31 | — | — | US | disclosed |
| EP-0535192-B1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | HOFFMANN LA ROCHE (CH) | 1996-06-19 | — | — | EP | disclosed |
| US-5486466-A | ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-01-23 | — | — | US | disclosed |
| CN-1114648-A | Novel monocyclic and bicyclic DNA gyrase inhibitors | HOFFMANN LA ROCHE (CH) | 1996-01-10 | — | — | CN | disclosed |
| EP-0675122-A2 | Mono or bicyclic DNA gyrase inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-04 | — | — | EP | disclosed |
| US-5399741-A | DNA gyrase inhibitors, process for their manufacture and pharmaceutical preparations containing same | HOFFMANN-LA ROCHE INC. (US) | 1995-03-21 | — | — | US | disclosed |
| US-5294609-A | Microbiocides | HOFFMANN-LAROCHE INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0535192-A1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME. | HOFFMANN LA ROCHE (CH) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992018490-A1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | F. HOFFMANN-LA ROCHE AG (CH) | 1992-10-29 | — | — | WO | disclosed |