Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 9/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | USP5 | P45974 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868495 | 0.91 | P4HTM (0.48) | P4HTMLIMK1LIMK2EGFRHDAC1 | |
| SCHEMBL8867875 | 0.89 | P4HTM (0.47) | P4HTMLIMK1LIMK2EGFRHDAC1 | |
| SCHEMBL9137310 | 0.89 | P4HTM (0.62) | P4HTMLIMK1LIMK2EGFRHDAC1 | |
| SCHEMBL8870065 | 0.89 | P4HTM (0.45) | P4HTMLIMK1LIMK2CA2EGFR | |
| SCHEMBL8868768 | 0.87 | P4HTM (0.43) | P4HTMLIMK1LIMK2EGFREGLN1 | |
| SCHEMBL8869042 | 0.87 | P4HTM (0.48) | P4HTMLIMK1LIMK2EGFRHDAC1 | |
| SCHEMBL8868783 | 0.86 | LIMK1 (0.48) | P4HTMLIMK1LIMK2CA2HDAC1 | |
| SCHEMBL8868788 | 0.85 | P4HTM (0.45) | P4HTMLIMK1LIMK2EGFRHDAC1 | |
| SCHEMBL8869765 | 0.85 | P4HTM (0.51) | P4HTMCA1CA2CA9EGFR | |
| SCHEMBL9140979 | 0.85 | P4HTM (0.53) | P4HTMLIMK1LIMK2EGFRHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |