Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868788 | 0.93 | P4HTM (0.45) | P4HTMLIMK1LIMK2EGFRBCL2L1 | |
| SCHEMBL8867875 | 0.92 | P4HTM (0.47) | P4HTMLIMK1LIMK2EGFRBCL2L1 | |
| SCHEMBL8868495 | 0.89 | P4HTM (0.48) | P4HTMLIMK1LIMK2EGFRBCL2L1 | |
| SCHEMBL9140979 | 0.88 | P4HTM (0.53) | P4HTMLIMK1LIMK2EGFRERBB2 | |
| SCHEMBL8869116 | 0.88 | P4HTM (0.53) | P4HTMEGFRBCL2L1MCL1ALDH1A1 | |
| SCHEMBL8869660 | 0.87 | P4HTM (0.48) | P4HTMLIMK1LIMK2EGFRERBB2 | |
| SCHEMBL7871568 | 0.86 | LIMK1 (0.41) | P4HTMLIMK1LIMK2EGFRBCL2L1 | |
| SCHEMBL8869547 | 0.86 | CA2 (0.52) | P4HTMEGFRBCL2L1MCL1ALDH1A1 | |
| SCHEMBL8870065 | 0.85 | P4HTM (0.45) | P4HTMLIMK1LIMK2EGFRBCL2L1 | |
| SCHEMBL9137310 | 0.85 | P4HTM (0.62) | P4HTMLIMK1LIMK2EGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |