Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417306 | 0.86 | HTT (0.73) | HTTPOLBFGFR1MKNK1MKNK2 | |
| SCHEMBL23266636 | 0.81 | HTT (0.60) | HTTPOLBFGFR1MKNK1MKNK2 | |
| SCHEMBL56852 | 0.79 | FGFR1 (0.61) | HTTPOLBFGFR1ALDH1A1 | |
| SCHEMBL23840256 | 0.79 | HTT (0.58) | HTTPOLBFGFR1MKNK1MKNK2 | |
| SCHEMBL4944401 | 0.78 | HTT (0.56) | HTTPOLBFGFR1MKNK1MKNK2 | |
| SCHEMBL23840275 | 0.78 | FGFR1 (0.58) | HTTPOLBFGFR1MKNK1MKNK2 | |
| SCHEMBL5937 | 0.78 | HTT (0.56) | HTTPOLBFGFR1MKNK1MKNK2 | |
| SCHEMBL8624088 | 0.78 | FGFR1 (0.59) | HTTPOLBFGFR1ALDH1A1 | |
| SCHEMBL7211112 | 0.78 | HTT (0.56) | HTTPOLBFGFR1ALDH1A1ROCK1 | |
| SCHEMBL12138417 | 0.78 | HTT (0.56) | HTTPOLBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991644-A2 | NONSTEROIDAL AND STEROIDAL COMPOUNDS WITH POTENT ANDROGEN RECEPTOR DOWN-REGULATION AND ANTI PROSTATE CANCER ACTIVITY | University of Maryland, Baltimore (US) | 2016-03-09 | — | — | EP | disclosed |
| WO-2014165815-A2 | NONSTEROIDAL AND STEROIDAL COMPOUNDS WITH POTENT ANDROGEN RECEPTOR DOWN-REGULATION AND ANTI PROSTATE CANCER ACTIVITY | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2014-10-09 | — | — | WO | disclosed |
| US-5683999-A | Cyclic urea HIV protease inhibitors | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-11-04 | — | — | US | disclosed |