Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5024090 | 0.88 | HTT (0.51) | HTTROCK1MKNK1MKNK2POLB | |
| SCHEMBL3417306 | 0.86 | HTT (0.73) | HTTROCK1MKNK1MKNK2POLB | |
| SCHEMBL23266636 | 0.81 | HTT (0.60) | HTTROCK1MKNK1MKNK2POLB | |
| SCHEMBL56852 | 0.79 | FGFR1 (0.61) | HTTPOLBFGFR1ALDH1A1 | |
| SCHEMBL23840256 | 0.79 | HTT (0.58) | HTTROCK1MKNK1MKNK2POLB | |
| SCHEMBL8624088 | 0.78 | FGFR1 (0.59) | HTTPOLBFGFR1ALDH1A1 | |
| SCHEMBL23840275 | 0.78 | FGFR1 (0.58) | HTTROCK1MKNK1MKNK2POLB | |
| SCHEMBL8869907 | 0.78 | HTT (0.56) | HTTROCK1MKNK1MKNK2POLB | |
| SCHEMBL5937 | 0.78 | HTT (0.56) | HTTROCK1MKNK1MKNK2POLB | |
| SCHEMBL7211112 | 0.78 | HTT (0.56) | HTTROCK1POLBFGFR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106349244-A | Benzo imidazo quinazoline dimethyl oxygen benzene oxygen acetyl-AA-OBzl, as well as synthesis, activity and application thereof | 首都医科大学 | 2017-01-25 | — | — | CN | claimed |
| EP-0001246-A1 | Preparation of 2-(3'- or 4'-aminophenyl)-5(or 6)-aminobenzimidazoles | CASSELLA Aktiengesellschaft (DE) | 1979-04-04 | — | — | EP | claimed |
| EP-3356369-B1 | BENZIMIDAZOLO[1,2-A]BENZIMIDAZOLE CARRYING TRIAZINE GROUPS FOR ORGANIC LIGHT EMITTING DIODES | IDEMITSU KOSAN CO (JP) | 2022-05-04 | — | — | EP | disclosed |
| US-11174258-B2 | Benzimidazolo[1,2-a]benzimidazole derivatives for organic light emitting diodes | IDEMITSU KOSAN CO., LTD. (JP) | 2021-11-16 | — | — | US | disclosed |
| EP-3356368-B1 | BENZIMIDAZOLO[1,2-A]BENZIMIDAZOLE CARRYING BENZIMIDAZOLO[1,2-A]BENZIMIDAZOLYL GROUPS, CARBAZOLYL GROUPS, BENZOFURANE GROUPS OR BENZOTHIOPHENE GROUPS FOR ORGANIC LIGHT EMITTING DIODES | IDEMITSU KOSAN CO (JP) | 2021-07-21 | — | — | EP | disclosed |
| EP-3150604-B1 | BENZIMIDAZOLO[1,2-A]BENZIMIDAZOLE CARRYING BENZIMIDAZOLO[1,2-A]BENZIMIDAZOLYLYL GROUPS, CARBAZOLYL GROUPS, BENZOFURANE GROUPS OR BENZOTHIOPHENE GROUPS FOR ORGANIC LIGHT EMITTING DIODES | IDEMITSU KOSAN CO (JP) | 2021-07-14 | — | — | EP | disclosed |
| EP-3318566-B1 | AZADIBENZOFURANS FOR ELECTRONIC APPLICATIONS | UDC IRELAND LTD (IE) | 2020-06-24 | — | — | EP | disclosed |
| US-10689385-B2 | Benzimidazolo[1,2-A]benzimidazole carrying aryl- or arylnitril groups for organic light emitting diodes | IDEMITSU KOSAN CO., LTD. (JP) | 2020-06-23 | — | — | US | disclosed |
| EP-3328860-B1 | PROCESS FOR THE PREPARATION OF BENZIMIDAZO[1,2-A]BENZIMIDAZOLES | UDC IRELAND LTD (IE) | 2020-03-04 | — | — | EP | disclosed |
| US-10570136-B2 | Process for the preparation of benzimidazo[1,2-a] benzimidazoles | UDC IRELAND LIMITED (IE) | 2020-02-25 | — | — | US | disclosed |
| EP-3174885-B1 | 2,9-FUNCTIONALIZED BENZIMIDAZOLO[1,2-A]BENZIMIDAZOLES AS HOSTS FOR ORGANIC LIGHT EMITTING DIODES (OLEDS) | IDEMITSU KOSAN CO (JP) | 2019-10-02 | — | — | EP | disclosed |
| US-20040116388-A1 | triazine compoound inhibitors of enzymes that catalyze phosphoryl transfer and/or that bind ATP/GTP nucleotides | AMGEN INC. | 2004-06-17 | — | — | US | disclosed |
| WO-2003082186-A2 | USE OF BENZIMIDAZOLE ANALOGS IN THE TREATMENT OF CELL PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2003-10-09 | — | — | WO | disclosed |
| US-20030100582-A1 | Benzimidazole compounds for regulating IgE | AVANIR PHARMACEUTICALS | 2003-05-29 | — | — | US | disclosed |
| EP-1218360-A1 | TRIAZINE KINASE INHIBITORS | Amgen Inc., (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001025220-A1 | TRIAZINE KINASE INHIBITORS | AMGEN INC. (US) | 2001-04-12 | — | — | WO | disclosed |
| EP-1028953-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999023091-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1999-05-14 | — | — | WO | disclosed |
| EP-0001246-B1 | PREPARATION OF 2-(3'- OR 4'-AMINOPHENYL)-5(OR 6)-AMINOBENZIMIDAZOLES | CASSELLA Aktiengesellschaft (DE) | 1981-02-25 | — | — | EP | disclosed |
| US-4192947-A | REACTING DIAMINO NITROBENZENE WITH NITROBENZOYL CHLORIDE, CYCLIZING ANILIDE IN AQUEOUS ALKALI, REDUCING NITRO GROUPS WITH SULFIDE | CASSELLA AKTIENGESELLSCHAFT (DE) | 1980-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100582-A1 | Benzimidazole compounds for regulating IgE | FCER2, SERPINB1, BRPF3 | HTT 4493/4885ROCK1 1812/4885MKNK1 2873/4885 |
| US-10570136-B2 | Process for the preparation of benzimidazo[1,2-a] benzimidazoles | CYP3A4, CYP2C19, CYP1B1 | HTT 3856/4885ROCK1 1441/4885MKNK1 1760/4885 |
| US-11174258-B2 | Benzimidazolo[1,2-a]benzimidazole derivatives for organic light emitting diodes | KCNH2, KCNH3, KCNJ2 | HTT 3699/4885ROCK1 1860/4885MKNK1 4248/4885 |
| US-10689385-B2 | Benzimidazolo[1,2-A]benzimidazole carrying aryl- or arylnitril groups for organic light emitting diodes | KCNB1, KCNJ2, KCNB2 | HTT 3362/4885ROCK1 4744/4885MKNK1 3032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.