Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 7/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.38 |
| ▸ | DPP4 | P27487 | 5/20 | 0.38 |
| ▸ | LONP1 | P36776 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | METAP1 | P53582 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870244 | 1.00 | DPP8 (0.38) | DPP8DPP9DPP7DPP4LONP1 | |
| SCHEMBL8869418 | 0.90 | DPP8 (0.36) | DPP8DPP7DPP4LONP1CPB2 | |
| SCHEMBL8869425 | 0.90 | DPP8 (0.36) | DPP8DPP7DPP4LONP1CPB2 | |
| SCHEMBL8870455 | 0.89 | DPP4 (0.37) | DPP8DPP9DPP7DPP4EPHX1 | |
| SCHEMBL8870452 | 0.89 | DPP4 (0.37) | DPP8DPP9DPP7DPP4EPHX1 | |
| SCHEMBL8870895 | 0.87 | DPP8 (0.38) | DPP8DPP9DPP7DPP4EPHX1 | |
| SCHEMBL8870902 | 0.87 | DPP8 (0.38) | DPP8DPP9DPP7DPP4EPHX1 | |
| SCHEMBL13576336 | 0.74 | DPP4 (0.38) | DPP8DPP9DPP7DPP4HDAC4 | |
| SCHEMBL8869666 | 0.73 | SMYD3 (0.33) | DPP4 | |
| SCHEMBL8869661 | 0.73 | SMYD3 (0.33) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624924-A | Quinobenzothiazine antineoplastic agents | ABBOTT LABORATORIES (US) | 1997-04-29 | — | — | US | claimed |
| US-5318965-A | Administering to treat leukemia, melanoma, carcinoma of lung, colon, ovaries | ABBOTT LABORATORIES (US) | 1994-06-07 | — | — | US | claimed |
| WO-1993016702-A1 | QUINOBENZOXAZINE, QUINOBENZOTHIAZINE, AND PYRIDO-ACRIDINE ANTINEOPLASTIC AGENTS | ABBOTT LABORATORIES (US) | 1993-09-02 | — | — | WO | claimed |
| US-5624924-A | Quinobenzothiazine antineoplastic agents | ABBOTT LABORATORIES (US) | 1997-04-29 | — | — | US | disclosed |
| US-5318965-A | Administering to treat leukemia, melanoma, carcinoma of lung, colon, ovaries | ABBOTT LABORATORIES (US) | 1994-06-07 | — | — | US | disclosed |
| WO-1993016702-A1 | QUINOBENZOXAZINE, QUINOBENZOTHIAZINE, AND PYRIDO-ACRIDINE ANTINEOPLASTIC AGENTS | ABBOTT LABORATORIES (US) | 1993-09-02 | — | — | WO | disclosed |