Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 17/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870773 | 0.87 | CYP3A4 (0.52) | CYP19A1CYP3A4CYP3A5 | |
| SCHEMBL31124841 | 0.82 | CYP2A6 (0.50) | CYP19A1USP2RAB9A | |
| SCHEMBL9651054 | 0.79 | CYP19A1 (1.00) | CYP19A1CYP3A4CYP3A5 | |
| SCHEMBL913343 | 0.78 | CYP19A1 (0.79) | CYP19A1CYP3A4CYP3A5 | |
| SCHEMBL17159521 | 0.77 | CYP19A1 (0.53) | CYP19A1CYP3A4CYP3A5 | |
| SCHEMBL8870724 | 0.75 | CYP19A1 (0.59) | CYP19A1CYP3A4CYP3A5 | |
| SCHEMBL10631898 | 0.73 | CYP19A1 (0.86) | CYP19A1CYP3A4CYP3A5USP2RAB9A | |
| SCHEMBL27282169 | 0.73 | CYP19A1 (0.86) | CYP19A1CYP3A4CYP3A5 | |
| SCHEMBL4432529 | 0.73 | ALDH1A1 (0.48) | CYP19A1CYP3A4 | |
| SCHEMBL13865450 | 0.73 | ALDH1A1 (0.48) | CYP19A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637605-A | ANTITUMOR AGENTS | CIBA GEIGY CORPORATION (US) | 1997-06-10 | — | — | US | disclosed |
| US-5583128-A | ADMINISTERING A SIDE EFFECT REDUCED AROMATASE INHIBITOR | CIBA-GEIGY CORPORATION (US) | 1996-12-10 | — | — | US | disclosed |
| US-5457209-A | Antitumor agents | CIBA-GEIGY CORPORATION (US) | 1995-10-10 | — | — | US | disclosed |
| US-5376669-A | Antitumor agents | CIBA-GEIGY CORP. (US) | 1994-12-27 | — | — | US | disclosed |
| US-5227393-A | estrogen-dependent diseases, anticancer | CIBA-GEIGY CORPORATION (US) | 1993-07-13 | — | — | US | disclosed |
| EP-0490816-A2 | Fluoro-compounds | CIBA-GEIGY AG (CH) | 1992-06-17 | — | — | EP | disclosed |