Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.64 |
| ▸ | MMP2 | P08253 | 7/20 | 0.35 |
| ▸ | MMP3 | P08254 | 7/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.35 |
| ▸ | MMP1 | P03956 | 5/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58652 | 1.00 | TUBB1 (0.64) | TUBB1MMP2MMP3ADAM17MMP1 | |
| SCHEMBL14233306 | 1.00 | TUBB1 (0.64) | TUBB1MMP2MMP3ADAM17MMP1 | |
| SCHEMBL4862472 | 1.00 | TUBB1 (0.64) | TUBB1MMP2MMP3ADAM17MMP1 | |
| SCHEMBL4372660 | 1.00 | TUBB1 (0.64) | TUBB1MMP2MMP3ADAM17MMP1 | |
| SCHEMBL58246 | 1.00 | TUBB1 (0.64) | TUBB1MMP2MMP3ADAM17MMP1 | |
| Trifluoroacetic Acid SCHEMBL4372079 | 0.96 | TUBB1 (0.60) | TUBB1MMP2MMP3ADAM17MMP1 | |
| Trifluoroacetic Acid SCHEMBL4372087 | 0.96 | TUBB1 (0.60) | TUBB1MMP2MMP3ADAM17MMP1 | |
| SCHEMBL13682456 | 0.92 | TUBB1 (0.64) | TUBB1MMP2MMP3ADAM17MMP1 | |
| SCHEMBL4368562 | 0.90 | TUBB1 (0.70) | TUBB1MMP2MMP3ADAM17MMP1 | |
| SCHEMBL13581415 | 0.90 | TUBB1 (0.70) | TUBB1MMP2MMP3ADAM17MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309938-A1 | HEMIASTERLIN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CANCER | EISAI CO., LTD. (JP) | 2012-12-06 | — | — | US | disclosed |
| EP-2374454-A1 | Hemiasterlin derivatives and uses thereof in the treatment of cancer | Eisai R&D Management Co., Ltd. (JP) | 2011-10-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309938-A1 | HEMIASTERLIN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CANCER | DHCR7, HSD17B7, HCCS | TUBB1 1330/4885MMP2 2548/4885MMP3 4096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.