Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.72 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.72 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.72 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.72 |
| ▸ | CXCR2 | P25025 | 6/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 9/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870945 | 1.00 | ABCC9 (0.72) | ABCC9ABCC8KCNJ11KCNJ8CXCR2 | |
| SCHEMBL8870610 | 0.86 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8CXCR2 | |
| SCHEMBL8870608 | 0.86 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8CXCR2 | |
| SCHEMBL6024203 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CXCR2 | |
| SCHEMBL4258934 | 0.84 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8CXCR2 | |
| SCHEMBL8870870 | 0.79 | MAPKAPK2 (0.65) | CXCR2MAPKAPK2AURKBROCK1CYP3A4 | |
| SCHEMBL9146091 | 0.79 | MAPKAPK2 (0.65) | CXCR2MAPKAPK2AURKBROCK1CYP3A4 | |
| SCHEMBL8871512 | 0.79 | MAPKAPK2 (0.65) | CXCR2MAPKAPK2AURKBROCK1CYP3A4 | |
| SCHEMBL8868951 | 0.79 | MAPKAPK2 (0.59) | CXCR2MAPKAPK2AURKBROCK1CYP3A4 | |
| SCHEMBL9148198 | 0.79 | MAPKAPK2 (0.59) | CXCR2MAPKAPK2AURKBROCK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5466712-A | Smooth muscle relaxants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-14 | — | — | US | claimed |
| US-5605909-A | REDUCING ADVERSE EFFECTS OF SMOOTH MUSCLE CONTRACTIONS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |
| US-5532245-A | TO REDUCE SMOOTH MUSCLE CONTRACTIONS; TREATMENT FOR URINARY INCONTINENCE, IRITABLE BOWEL SYNDROME | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-07-02 | — | — | US | disclosed |
| US-5466712-A | Smooth muscle relaxants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-14 | — | — | US | disclosed |