Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.81 |
| ▸ | FBP1 | P09467 | 3/20 | 0.68 |
| ▸ | KDR | P35968 | 7/20 | 0.65 |
| ▸ | SRC | P12931 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.65 |
| ▸ | ABL1 | P00519 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.65 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.65 |
| ▸ | GAK | O14976 | 1/20 | 0.65 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.65 |
| ▸ | CDK1 | P06493 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2099775 | 0.90 | EGFR (0.83) | EGFRFBP1KDRSRCKDM4E | |
| SCHEMBL5482883 | 0.90 | EGFR (1.00) | EGFRFBP1KDRSRCKDM4E | |
| SCHEMBL31060707 | 0.90 | EGFR (1.00) | EGFRFBP1KDRSRCKDM4E | |
| SCHEMBL2101009 | 0.89 | EGFR (0.81) | EGFRFBP1KDRSRCKDM4E | |
| SCHEMBL4232360 | 0.89 | FBP1 (0.84) | EGFRFBP1KDRSRCKDM4E | |
| Hydrochloric Acid SCHEMBL5478587 | 0.89 | EGFR (0.97) | EGFRFBP1KDRSRCKDM4E | |
| SCHEMBL8871648 | 0.88 | EGFR (0.78) | EGFRFBP1KDRSRCKDM4E | |
| SCHEMBL799667 | 0.87 | EGFR (0.78) | EGFRFBP1KDRSRCERBB2 | |
| SCHEMBL8870952 | 0.87 | EGFR (0.76) | EGFRFBP1KDRSRCKDM4E | |
| SCHEMBL19885292 | 0.86 | EGFR (0.74) | EGFRFBP1KDRSRCKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616582-A | Use as anticancer agents; e.g. gefitinib | ZENECA LIMITED (GB) | 1997-04-01 | — | — | US | disclosed |
| EP-0566226-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1995-11-08 | — | — | EP | disclosed |
| US-5457105-A | anticancer use; e.g. 4-(3'-chloro-4'-fluoroanilino)-6,7-dimethoxyquinazoline (gefitinib) | ZENECA LIMITED (GB) | 1995-10-10 | — | — | US | disclosed |
| EP-0566226-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1993-10-20 | — | — | EP | disclosed |