Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 4/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324923 | 0.70 | KMT2A (0.41) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL23627241 | 0.61 | CHRM3 (0.44) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL27488628 | 0.61 | CHRM3 (0.44) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9833055 | 0.60 | KDM4E (0.41) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5798986 | 0.60 | — | — | |
| Dimethyl Phthalate SCHEMBL27488190 | 0.60 | TSHR (0.65) | LMNACA9TSHRCA1CA2 | |
| SCHEMBL866607 | 0.60 | RAB9A (0.58) | LMNATSHRALDH1A1NPC1MAPT | |
| SCHEMBL5600204 | 0.59 | CA12 (0.59) | CA12CA9CA2ALOX15 | |
| SCHEMBL5906945 | 0.59 | PTPN1 (0.50) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10431184 | 0.59 | CHRM3 (0.50) | CHRM3CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686463-A | Oxadiazoles useful in the treatment of senile dementia | MERCK, SHARP & DOHME, LTD. (GB) | 1997-11-11 | — | — | US | disclosed |
| EP-0239309-B1 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-01-12 | — | — | EP | disclosed |
| CN-87102972-A | Treatment senile dementia oxadiazoles useful | — | 1987-11-18 | — | — | CN | disclosed |
| EP-0239309-A2 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1987-09-30 | — | — | EP | disclosed |