Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871000 | 0.97 | HTR1A (0.62) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8871067 | 0.90 | HTR1A (0.66) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8870688 | 0.88 | HTR1A (0.70) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8871781 | 0.86 | HTR1A (0.60) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8870986 | 0.86 | HTR1A (0.65) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8554055 | 0.85 | HTR1A (0.61) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8871366 | 0.84 | HTR1A (0.65) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8871687 | 0.84 | HTR1A (0.64) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8871208 | 0.84 | HTR1A (0.56) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8870571 | 0.84 | HTR1A (0.69) | HTR1AADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693655-A | 3-indolylpiperidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-02 | — | — | US | disclosed |