Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8872395 | 0.90 | CHRM2 (0.48) | CHRM2CHRM1 | |
| SCHEMBL8871957 | 0.82 | CHRM2 (0.47) | CHRM2CHRM1 | |
| SCHEMBL8872594 | 0.79 | CHRNB2 (0.35) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL8873659 | 0.79 | CHRM2 (0.46) | CHRM2CHRNB2CHRNA7CHRNA4 | |
| Hydrochloric Acid SCHEMBL8872420 | 0.78 | CHRNB2 (0.34) | CHRNB2CHRNA7CHRNA4 | |
| Hydrochloric Acid SCHEMBL8871582 | 0.78 | CHRM2 (0.45) | CHRM2CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL15934098 | 0.70 | CHRM2 (0.48) | CHRM2 | |
| SCHEMBL8871950 | 0.69 | CHRM2 (0.50) | CHRM2CHRM1 | |
| SCHEMBL9490384 | 0.69 | CHRM2 (0.57) | CHRM2CHRM1 | |
| SCHEMBL16935071 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686463-A | Oxadiazoles useful in the treatment of senile dementia | MERCK, SHARP & DOHME, LTD. (GB) | 1997-11-11 | — | — | US | claimed |
| EP-0239309-B1 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-01-12 | — | — | EP | claimed |
| US-5686463-A | Oxadiazoles useful in the treatment of senile dementia | MERCK, SHARP & DOHME, LTD. (GB) | 1997-11-11 | — | — | US | disclosed |
| EP-0239309-B1 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-01-12 | — | — | EP | disclosed |
| EP-0239309-A2 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1987-09-30 | — | — | EP | disclosed |