Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 9/20 | 0.59 |
| ▸ | ACHE | P22303 | 6/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8595390 | 1.00 | METAP1 (0.59) | METAP1ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL8595392 | 1.00 | METAP1 (0.59) | METAP1ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL8875167 | 0.85 | METAP1 (0.67) | METAP1ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL8598137 | 0.85 | METAP1 (0.67) | METAP1ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL8596188 | 0.84 | CYP19A1 (0.43) | METAP1ACHE | |
| SCHEMBL8600861 | 0.84 | METAP1 (0.47) | METAP1ACHEPARP1PARP10 | |
| SCHEMBL8874593 | 0.84 | CYP19A1 (0.43) | METAP1ACHE | |
| SCHEMBL8873173 | 0.84 | ACHE (0.55) | METAP1ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL8596659 | 0.84 | ACHE (0.55) | METAP1ACHEHTR2AHTR2CHTR2B | |
| SCHEMBL8595939 | 0.84 | METAP1 (0.47) | METAP1ACHEHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |